Algorithm and tool development for microbiome studies

Microbes are everywhere and they play important roles in sustaining life. Thanks to the development of sequencing technologies and others, microbiome studies have produced massive metagenomic data, and more recently other meta-omics including metatranscriptomic and metaproteomic data associated with different ecosystems, habitats and hosts, revealing insights into the composition, function and regulatory characteristics of the microbial communities. Analyzing microbiome data is computationally demanding, and still remains challenging.

Understanding the CRISPR–Cas systems and their applications (tools developed)

Protein sequence-structure-function relationship

Biological network

Fig 3. Domain combination comparison by CADO

Fig 4. Pathway variant detection